Abstract
It was reported that hypophysectomy abolished analgesia in acupuncture anesthesia (AA) measured by tail-flick and vocalization tests in rats. However, Fu et al reported that hypophysectomy did not influence AA measured by writhing test using phenylquinone in mouse. In the present experiment, the effect of hypophysectomy on AA measured by writhing test in rats has been investigated. Intraperitoneally applied 2.5 mg/kg phenylquinone caused writhing. Acupuncture stimulation completely abolished writhing behavior in acupuncture effective animals classified by the tail-flick test. After hypophysectomy, acupuncture stimulation did not prevent writhing caused by phenylquinone. The difference between Fu's results and those here might be the difference in analgesia caused by different acupuncture stimulation, since Fu's AA was not blocked by naloxone, while our AA was blocked completely, and Fu's AA was slightly reduced by hypophysectomy, while our AA was completely abolished. It was concluded that hynonhvsectomv completely abolished naloxone reversal AA measured by writhing test.
