Abstract
5-FU levels in gastric juice, pancreatic juice and bile were examined chemically after 10 mg/kg 5-FU and 20 mg/kg Tegaful bolus iv. injections, respectively, in dogs. In the case of 5-FU administration, appearance of 5-FU was very short with a steep peak, 0.996μg/ml in 20 min., in gastric juice, 9.85μg/ml in 10 min. in bile. In addition, a decreasing curve was also steep in pancreatic juice and bile. But, in gastric juice, the decreasing curve was very slow and, rather, was sustained with 0.238μg/ml in 60 min. In the case of Tegaful administration, it appeared in all three fluids within a short time, and its content revealed its highest value in 10 min. in bile and pancreatic juice and in 30 min. in gastric juice. After Tegaful appeared in these fluids, it was slowly converted to 5-FU. 5-FU concentration peak was 0.085μg/ml in 40 min. in gastric juice, 0.069μg/ml in 10 min, in pancreatic juice and 0.269μg/ml in 30 min. in bile. Above findings suggest strongly that the application of a fluorinated pyrimidine is most reasonable in treatment of GI malignancies, but further studies are necessary.
