Abstract
The effect of atenolol on lipid metabolism in the spontaneous hypertensive rats (SHR) were investigated by the determination of lipid contents in the serum, liver and aorta. Male SHR at 5 weeks of age were used. Rats were given 20 and 100 mg/kg/day of atenolol orally for 10 weeks. Blood pressure and heart rate were inhibited in dependence on a dose of atenolol the whole of the experimental period. Serum triglyceride (TG) were significantly decreased by the administration of atenolol at a dose of 100 mg/kg. Other serum lipids were not changed by the administration of atenolol. The lowering of serum transaminase (GOT) by atenolol at a dose of 100 mg/kg were seen at 2, 4, 8 and 10 weeks of administration. Liver total cholesterol and TG tended to increase at the early weeks of administration at dose of 20mg/kg and later weeks of administration at a dose of 100 mg/kg. Aorta lipid contents were not changed after administration of atenolol. Atenolol caused a mild chages on the lipid metabolism than the other IS-blocking agent (e. g. propranolol) . These results suggest that the continuative treatment of atenolol has a rare posibility inducing the abnormality of lipid contents.
