A CASE OF THE FATAL SPLENIC RUPTURE IN MALIGNANT HISTIOCYTOSIS

Abstract

We reported a case, 71, years old male, with malignant histiocytosis who died of splenic rupture. He was admitted to our hospital because of fever, anemia and hepatosplenomegaly. Laboratory findings were as follows; Hb 11.7 g/dl, pits 11.7×10⁴/μl, WBC 6200/μl. Bone marrow finding showed 20.2% of tumor cells which morphology revealed characteristics of histiocyte. We treated only with 40 mg/day of prednisolone. On the 21 hospital days, he suddenly developed severe acute abdominal pain with hyprovolemic shock and died soon. Pathological findings were as follows: The spleen was ruptured. Diffuse infiltration of tumor cells which showed erythrophagocytosis were existed in bone marrow, liver, spleen and lymph node.