A CASE OF THE DUBIN-JOHNSON SYNDROME COMPLICATD WITH DIABETES MELLITUS

Abstract

A 52-year-old housewife visited our clinic with the complaint of a continuous genereal fatigue. She had already been pointed out icterus of the conjunctiva bulbi from her childhood and medicated by a homedoctor, being followed up the slight disturbance of her liver function. Plasma total bilirubin concentration was 4.5mg/dl. Direct bilirubin in plasma was 3.9mg/dl. The other laboratory tests were normal expect for γ-GTP concentration. Diabetus mellitus was diagnosed by employing a 75g OGTT. Free blood sugar concentration was 219mg/dl.
By the laparotomy, the gray-black color of the liver was confirmed. The biopsied liver specimen showed various features, i.e. distinctive dark brown Dubin-Johnson pigments, degeneration of the hepatic cells due to both active hepatitis and Diabetus mellitus, and fibrosis.