EFFECTS OF γ-ORYZANOL AND ITS RELATED COMPOUNDS ON TRITON INDUCED HYPERLIPIDEMIA IN RATS

Abstract

The changes of serum lipids at 8, 24 and 43 hour after administration of triton WR-1339 (Triton) were investigated, and the effects of γ-oryzanol (γ-OZ) and its new sterol compositions (N-γ-OZ) and cycloartenol ferulic acid ester (CAF) on this hyperlipidemic model were examined by the oral and intravenous administrations. The marked increase of total cholesterol (TC), free cholesterol (FC), triglyceride (TG) and phospholipid (PL) and the significant decrease of TC and PL in high density lipoprotein were found by the intravenous administration of Triton, and reached a peak at 24 hour after administration. In the investigations of lipid synthesis, the animals at 8 to 24 hour after administration of Triton 250mg/kg were good model. In contrast, the animals at 43 hour after administration of Triton 300mg/kg were good model on the investigations of lipid excretion. γ-OZ, N-γ-OZ and CAF were not inhibited the increases of TC, FC, TG and PL in the serum at 8 to 24 hour after administration of Triton 250 and 300mg/kg. The excretion of lipids at 43 hour after administration of Triton 300mg/kg was accelerated by the intravenous administrations of γ-OZ, N-γ-OZ and CAF. The order of effects on the lipid excretion in Triton induced hyperlipidemia was γ-OZ<CAF≤N-γ-OZ.