Abstract
As we experienced Eosinophilic lymphofolliculosis of the skin (so-called Kimura's disease) which resisted treatments, a report is made with some bibliographic consideration. The case was a male aged 44. The patient is undergoing dialysis at our hospital since August, 1979, due to amyloidosis and chronic renal failure, and a tumescence developed in the left frontauricular region. Excision of the legion was made under general anesthesia at our surgical department on May 25 of the same year. As a result, diagnosis of Kimura's disease was made. Development of the tumescence recurred in the left front auricular region around from August, 1982. The patient visited our department to have Sialography on January 11, 1983. Treatment was made with oral administration of steroid and Tranilast. Tranilast is a condensed agent consisting of a derivative of cinamic acid contained in nandin and anthranilic acid which is a protein metabolite. The drug has been developed in Japan as an agent which can be administered orally to inhibit release of chemical mediator. The drug is known to have inhibitory activities not only on type I reaction but on type II and III reactions. Administration of Tranilast was continued for more than 2 years as we judged this disease as that caused by type I allergy, but no control was possible against the tumescence. Even from the aspect of the pharmacological actions peculiar to Tranilast, the disease can be considered as a mixed type allergic reaction participated not only by types I, II and i but also byIV (delayed type) .
