Abstract
Scorpion venom has been known as a drug causing marked hypersecretion to pancreas. By use of the venom, the early pancreatic fibrosis has been investigated. In histlogical findings, the cases in short term (up to 14 days) provided swelling and degeneration of acinar cells, also accompanying with marked edema on its interstitium. The cases in middle term (up to 120 days), the extent of edema was much more increasing with an extension of experimental period, a part of these damages developed into scleroedema, at which it contained fibril to be electromicroscopically determined, seen on its interstitium occupying around the capillary. The cases in long term (more than 120 days) finally permitted the pancreas to change into intralobular fibrosis, under such a situation fibroblastoid cells with various forms appeared on the interstitium, which was filled with a large amount of collagen fiber and fibril, also contained a little amyloid-like fine fiber. In conclusion, the main mechanism to the scorpion fibrosis is to allow the pancreas to change into scleroedema for the pancreatic interstitum to be frequently repeated marked edema, and its process can be activated the fibroblastoid cell. From above, that this point is to pancreas what the active fibrosis to liver must be considered.
