PHARMACOLOGICAL STUDIES ON PANAX NOTOGINSENG EXTRACT (HK 302)

I. ANTI-INFLAMMATORY ACTION

Abstract

A study was made on the effect of HK302 (freeze-dried powder of ethanol extract from roastedPanax Notoginseng) on the animal models for acute inflammation. Oral administration of HK302 (2000mg/kg) inhibited slightly rat paw edema induced by carrageenin, but did not inhibit increasing vascular permeability in the mouse peritoneal cavity induced by acetic acid. While Indomethacin, used as a positive drug, (30mg/kg, p.o.) showed strong inhibitory effect on both animal models. These results indicate that oral administration of HK302 does not provide remarkable effect on the inflammatory response.