Abstract
Glomerular alterations in autopsy of chronic alcoholic liver disease (fatty liver 42 cases, fatty liver cirrhosis 28 cases) were examined by light microscope and immunohistochemical methods. Pathological manifestation was increased amounts of mesangial matrix. This lesion was present in 73.2% of the fatty liver and 100% of the fatty liver cirrhosis cases. In 29.3% of the fatty liver and 67.9% of the fatty liver cirrhosis changes were more than moderate. In 46.7% of the fatty liver and 57.1% of the fatty liver cirrhosis cases, IgA immunoglobulin rate was positive by immunohistology. The results inferred that glomerular lesion is associated with IgA immunoglobulin. The glomerular scar rate was higher in alcoholic liver diseases than in contrast cases and non-alcohol cirrhotic cases. This scar was considered to be a hypertentional change. These studies confirmed that glomerular lesion of alcoholic liver diseases (fatty liver and fatty liver cirrhosis) are similar to non-alcoholic liver cirrhosis, and that glomerular scars are due to the effect of alcohol.
