PRIMARY BILIARY CIRRHOSIS WITH MARKED Cu DEPOSITION IN HEPATIC TISSUE

A CASE REPORT AND HISTOLOGICAL STUDY OF 8 CASES OF TYPICAL PRIMARY BILIARY CIRRHOSIS

Abstract

We report here a case of primary biliary cirrhosis (PBC) with marked Cu deposi-tion in hepatic tissue. Cu granules were revealed in hepatic cells in the peripheral part of the hepatic lobe in hepatic tissue stained by rhodanine. They were also revealed in Kupffer cell and Macrophages of Glisson's capsules. In further study of 8 other cases with typical PBC, Cu granule deposits were revealed in the peripheral part of the hepatic lobe, which tend. ed to be marked in the progressed stage. However Cu deposition, serous Cu and bile stagnation didn't show parallel courses. Thus, long term bile stagnation with crisis of the interlobu-lar bile duct, affects on Cu deposition in hepatic tissue.