Abstract
A 73-year-old man was admitted to our hospital with high fever and anergic stupor. After admission, the above symptoms continued, and diaphoresis, tachycardia and muscular rigidity developed. Laboratory data showed leukocytosis (14540/mm), and high serum levels of CPK (2255 IU) and LDH (1018 U) . As he had been taking diltiazem, dipyridamole, indomethacine, and diazepam habitually for about 5 years, and syndrome malin (SM) was suspected. Despite intensive care in administration of dantrolen sodium, bromocriptine mesilate and levodopa, impaired glucose tolerance, DIC and acute renal failure developed, and he died of SM on the 12th hospital day. Since drugs may cause serious side effects, especially in exhausted patients, careful use of drugs in combination with other drugs must be strongly emphasized.
