Abstract
For the purpose of establishing a selective heating method for tumors located deep, ferromagnetic substance was selectively incorporated into the tumor, and high frequency electromagnetic waves were need to induce heat. Magnetic iron oxide (tri-iron tetraoxide) particles, 150Å mean particle size, were coated with liposomes having no immunogenicity or toxicity, and bonded with hematoporphyrin, a substance with affinity to the tumor, to prepare the liposomal ferromagnetic particles (HP-LM) . In heating tests on rabbits, after tumor grafting (VX-2) into the lower thigh, HP-LM was inoculated at 100 mg/kg into the femoral artery. The following groups, A, B and C, were heated for 20 minutes each, by a high frequency inductive heater, once a week, 3 times in all. Group A received one does ; group B received two doses ; and group C were the control group. Significant differences temperature elevation and tumor retraction were noted in the respective group. Arterial injection accumulated HP-LM in the tumor tissue, and intermittent heating by high frequency electomagnetic waves retracted the tumor. This method is suggested for benefisial heating effects.
