Abstract
Serum creatine kinase (CK) and CK isoenzymes were measured in several cerebrovascular conditions (subarachinoid hemorrhage [SAH], intracerebral hemorrhage [ICH], and cerebral infarction [CI] ), brain tumor, and head injury. The differences in serum total CK activities between SAH and ICH were large. In 4 of 20 cases of SAH and 3 of 9 cases of ICH, serum total CK values were higher than the reference value. Serum CK isoenzyme levels (non-CK-M activity and CK-MB protein) were also high; 8 cases of SAH (40 %), they were higher than the reference value. The CK-BB isoenzyme was detected by electrophoresis in 3 cases of SAH. On the other hand, in ICH, values of serum CK isoenzymes were almost the same levels as the reference value. Serum total CK activity and CK isoenzymes varied within the reference values; in no case were the levels higher than the reference values. Serial changes of serum CK and CK isoenzymes were observed after surgery for SAH ; total CK activity increased 0.5 day after surgery, and reached a maximum of 1500 to 2500IU/l between 1 and 1.5 days after surgery. The CK activity decreased to the reference value 6 to 7 days after surgery. The change in CK isoenzymes levels were similar. CK-BB was detected by electrophoresis in some cases, but its appearance was not dependent on the complexity of the operation.
