THE EFFECTS OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) ON MASSIVE SMALL INTESTINAL RESECTION WITH OR WITHOUT ILEOCECAL RESECTION IN RATS

Abstract

Massive resection of the small intestine with or without the ileocecal region is sometimes done in gastrointestinal surgery, but its prognosis is not always satisfactory. Insulin-like growth factor-1 (IGF-1) can promote intestinal proliferation which may be beneficial to postoperative conditions after massive resection of the small instestine.
Therefore, we investigated the effects of IGF-1 on postperative conditions after massive resection of the small intestine with or without the ileocecal region in rats.
Six-week-old male Wistar rats were subjected to massive resection of the small intestine with or without the ileocecal region and continuously administered with IGF-1 or saline until the 7th postoperative day. Serum levels of GOT, GPT, total protein and transferrin were measured. Changes in the levels of body weight, water intake, urine volume and food intake were monitored.
Postoperative serum levels of GOT, GPT, total protein and transf errin, and body weight levels after massive resection of the small intestine without the ileocecal region were not significantly different from the preperative levels, and a distinct effect of IGF-1 was not recognized. However, these levels after massive resection of small intestine with the ileocecal region were decreased significantly from the preoperative levels and the decreased levels were significantly improved by the administration of IGF-1.
The results suggest that administration of IGF-1 has a clinical benefit to improve liver dysfuction and nutritional impairment caused by massive resection of the small intestine with the ileocecal region.