Abstract
On 130 cases of primary breast cancer who received srgery in Showa University Hospital from 1990 to 1992, we investigated the relation of the presence of hormone receptor, MIB-1, p53, c-erbB-2 and prognosis retrospectively. On formalin-fixed paraffin-embedded sections, following antibody, estrogen receptor (ER), progesterone receptor (PR), MIB-l, p53, and c-erbB-2 were used for immnohistochemical staining by the labelled streptavidin biotin method. We investigated the prognostic value with histological subtype, grading, and clinicopathological factors. Immnohistochemically, 68.5% of cases were positive in ER, 53.8% in PR, 39.2% in MIB-1, 50.8% in p53, 66.2% in c-erbB-2, respectively. An increase of MIB-1 positive cells, positive for p53, and c-erbB-2 were correlated with poor prognosis. In particular, MIB-1 increased and p53 positive cases were 69.2% in overall survival of five years ; therefore, this combination was a good indicator to estimate prognosis.
