Abstract
It has been reported that induced heat shock protein (HSP) is a factor in the acquisition of tolerance to stress. In the present study we investigated whether HSP70 is induced in the rat liver by warm ischemia preconditioning as well as by heat shock, and the time course of HSP70 immunostaining histologically. The expression of HSP70 in the nuclei of hepatocyts in the pericentral region was oberved. Only a few immunostainings of HSP70 were seen in the periportal area. HSP70 induced by warm ischemia was detected earlier than by heat shock. A short time period of warm ischemia was enough to induce HSP70. After subsequent warm ischemia, reperf usion time was shorter, ischemic preconditioning time was longer, and the expression of HSP70 was observed earlier therefore maintaining homeostasis. According to the tolerance acquisition by the induced HSP, it is speculated that occlusion of hepatic blood flow by Pringle's maneuver is associated with the protection of the liver.
