CORRELATION WITH MULTIDRUG RESISTANCE AND RECURRENCE IN HUMAN BREAST CANCER

Abstract

On 60 cases of breast cancer with lymph node metastasis who received surgery in Showa University Hospital from 1994 to 1998, we investigated the relation of estrogen receptor (ER), Her-2, histological grade, multidrug resistance (MDR-1 MRP-1, MRP-2), MIB-1, topoiso melase- II, and recurrence retrospectively. On f ormalin-fixed paraffin-embedded sections, following antibody, ER, Her-2, MIB-1, MDR-1, MRP-1, MRP-2 were used for immunohistochemical staining. We investigated the recurrence value with clinical factors, MIB-1 labeling index, toppisomelase- II labeling index and expression of ER, Her-2, MRP-1. Immunohistochemically, 1.7% of cases were positive in MDR-1, 68.3% of cases were positive in MRP-1, 96.7% of cases were positive in MRP-2, respectively. An expression of MRP-1 and an increase of MIB-1 labeling index correlated with risk of recurrence. Therefore, MRP-1 was a good indicator to predict recurrence.