Abstract
In order to obtain precise measurements and analysis of the splenic circulation in which both slow and fast phase coexist, we applied two kinds of analytic methods. For the slow phase, three compartments analysis was adopted using a radiosplenogram and a blood dilution curve with a tracer injected into antecubital vein. For the fast phase analysis the tracer was injected into the celiac artery and the radiosplenogram was subjected to simulation analysis with an analog computer. In the latter procedure the transfer function of heart-lung system to spleen dynamics was computed and applied to the precise evaluation of recirculation component.
The first circulation component was determined by subtracting the recirculation component from the original RSG. Thus the transfer function of the spleen in the fast phase was reduced.
With results of two analysis in each phase, a whole model of splenic circulation was constructed with distribution ratios to flow in and with rate constants to flow out of three compartments which were supposed to exist in the spleen. Aiming at clarifying the dynamics relationship among heart-lung, spleen and sykemic circulation, several simulation experiments were carried out with this model. These results were useful in applying this method to practice.
