Fundamental Investigations on Tumor Detection Method by Nuclear Magnetic Relaxation Time
1976 Volume 14 Issue 1 Pages 25-32
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1976 Volume 14 Issue 1 Pages 25-32
Since R. Damadian suggested the detectability of tumors by nuclear magnetic resonance (NMR), the authors have focused their attention on the facts such as the quantities related to the kinds of water and tissues. And at least qualitative information could be non-invasively obtained.
In this paper, in order to clarify the applicabilities of our proposed magnetic focusing method for non-invasive tumor detection, the nuclear magnetic relaxation time (T1) of transplanted malignant tumor (AH-66) in rat, excised normal and cancerous tissues in man were measured in vitro experiment.
The resultant findings are summarized as followings.
1) Transplanted malignant tumor in rat showed (30-120) % longer value of T1 than that of the respective normal tissues.
2) In 14 cases of the uterus, breast and stomach in man, the T1 of cancerous tissues increased (10-150) % than that of their normal portions.
3) When mixed tissue was studied, T1 changed as the ratio of tumor to normal tissue changed.
4) The longer the time elapsed, the greater the T1 value exhibited by normal and the smaller the T1 measured for cancerous tissue. When both normal and cancerous tissues coexist, T1 decrement of the tissue is small.
