Abstract
The multivariate analysis was applied to groups of blood dyscrasia : hereditery spherocytosis (HS) and autoimmune hemolytic anemia (AHA), to find out the index which reflects the dependency on the spleen of red blood cell destruction. In HS, almost all red cells are destroyed selectively in the spleen, so the splenectomy is the most effective treatment. But the cells of AHA are not always destroyed only in the spleen. According to whether or not the feature of its cell destruction is close to HS, the splenectomy should be indicated. After 51Cr injection to subjects, 4 observations were obtained : the blood destruction rate λ, RI accumulation rate in the spleen Δ (Sp/H), RI accumulation rate in the liver Δ (Liv/H), and the splenic volume per body weightSV. As the fifth value the ratio of Δ (Sp/H) to Δ (Liv/H) was introduced since this could be regarded as the approximation of the inde. To obtain more accurate index, the linear discriminant function and the quadratic function are chosen. With the set of these 5 variables both functions were carried out without variable transformation. And with another 2 sets, i. e., (λ, Δ (Sp/H), Δ (Liv/H), SV) and (λ, Δ (Sp/H) /Δ (Liv/H), SV), these procedures were appliedafter the logarithmic transformation.
The following are the results. 1) Δ (Sp/H) /Δ (Liv/H) which was introduced as the approximation index was not so effective. 2) Less subjects of AHA were discriinated from HS by the linear function than by the quadratic one. 3) The discriminant criteion on the non-transformed data seems to be less strict than on the logarithmic transformation. 4) The quadratic function gives more distinct discrimination than the linear function. 5) The contribution order of the variables are as follows ; SV, λ, Δ (Sp/H) Δ (Liv/H), Δ (Sp/H) and Δ (Liv/H). 6) Among 18 AHA subjects, one has features almost identical with HS, two have features close to HS, while the rest have a different features.
