Abstract
Thallium-201(T1-201) kinetics will offer useful information on the interpretation of clinical data. The fractionation principle has been believed to be applicable to the uptake of T1-201 which shows recirculation, but it seems to be applied as approximation. In this paper, the uptake was simulated in the system where T1-201 level of blood leaving the myocardium reaches an equilibrium with that of myocardium at each moment. Fick's principle was used. In this system, the flow rate was found to affect only the early phase of the uptake process. The final level was mostly defined by the blood level of T1-201 and the partition coefficient. The dependency of uptake level on the blood level was found in the two-successive administrations of T1-201. Changes in heart rate or glucose and insulin solution were found to affect the final level of T1-201 uptake. This may mean the possibility of an alteration in the blood-myocardium transport capability, when these interventions were given.
