Abstract
Application of MRSI (Magnetic Resonance Spectroscopic Imaging) for proton chemical shift to noninvasive medical thermometry was studied theoretically and experimentally. In vitro experiments using a 9.4T spectrometer clarified that a proton chemical shift between water (-OH) proton and fat (-CH2-) proton in each bovine organ such as tissue flap of muscle, liver, stomach wall, large intestinal wall and heart muscle is inversely proportional to temperature; The chemical shift between water and fat peak varied quite linearly about from 3.4ppm to 3.2ppm depending on tissue temperature in the range of 300K (27°C) to 318K (45°C) showing tissue insensitivities. For temperature imaging, multivoxel proton spectroscopy techniques are theoretically available. Development of a suitable multivoxel spectroscopy method for the thermometry and investigations about biological reactions including influence of pH are necessary.
