Japanese journal of medical electronics and biological engineering
Online ISSN : 2185-5498
Print ISSN : 0021-3292
ISSN-L : 0021-3292
Analysis of Left Ventricular Pumping by its Pressure-Volume Coefficient
Hiroyuki SUGA
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1969 Volume 7 Issue 6 Pages 406-415

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Abstract
Time course of the changes in left ventricular pressure-volume coefficient in a cardiac cycle, defined as e (t) =p (t) /v (t), where t=time from the beginning of the cardiac cycle, p (t) = systolic intraventricular pressure and v(t) = systolic intraventricular volume, is studied on anesthetized and thoracotomized dogs. For actual computation, v (t) = (1-ρ) -1·vs-∫t0i (t)dt, where ρ=residual volume ratio of the left ventricle measured by a thermodilution method, vs= stroke volume and i(t) = ascending aortic blood flow by an electromagnetic flowmeter. It is demonstrated that e(t) is approximately independent from intraventricular end-diastolic volume and from conditions of the arterial system, but is characteristically dependent on the strength of cardiac sympathetic stimulation and heart rate.
A model of the left ventricular pumping is proposed with e(t), and the results of its theoretical analysis are in satisfactory agreement with many investigated relationships among circulatory variables in cardiovascular physiology.
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© Japanese Society for Medical and Biological Engineering
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