Microbes and Environments
Online ISSN : 1347-4405
Print ISSN : 1342-6311
ISSN-L : 1342-6311
Minireview
Bacterial Signal Transduction Systems for Environmental Adaptation and Their Inhibitors
Ryutaro Utsumi
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JOURNAL FREE ACCESS

2002 Volume 17 Issue 1 Pages 1-5

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Abstract
Bacterial two-component signal transduction systems (TCSs) play a pivotal role in environmental adaptation. In this minireview, two TCSs in Escherichia coli are clarified: the PhoP/PhoQ system, which senses extracellular Mg2+ and controls the expression of the genes for adaptation to environmental Mg2+ deprivation (Mg2+ regulon); and EvgA/EvgS, a signal transduction system that activates expression of the drug efflux pump genes. Furthermore, based on the inhibition of YycF/YycG signal transduction in Bacillus subtilis, a novel strategy for developing a new class of antibacterial agents is described.
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© Japanese Society of Microbial Ecology / Japanese Society of Soil Microbiology / Taiwan Society of Microbial Ecology
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