Microbes and Environments
Online ISSN : 1347-4405
Print ISSN : 1342-6311
ISSN-L : 1342-6311
Short Communications
Morphological Effects of Sinefungin, an Inhibitor of S-Adenosylmethionine-Dependent Methyltransferases, on Anabaena sp. PCC 7120
Hironori FujitaKunihiko SyonoYasunori MachidaMasayoshi Kawaguchi
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2008 Volume 23 Issue 4 Pages 346-349


Anabaena cells develop regular one-dimensional filaments through cell division in planes parallel to each other. A gcvP mutant displayed morphological defects such as filaments with sharp bends and/or branching and irregular cell clumps. The defects probably result from depletion of S-adenosylmethionine (AdoMet), because they were rescued by the application of methionine, an AdoMet precursor, and because sinefungin, a strong inhibitor of AdoMet-dependent methyltransferases, caused morphological abnormalities in wild-type Anabaena similar to those of the mutant. AdoMet-dependent methylation is involved in the spatial regulation of cell polarity in Anabaena.

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