Abstract
Cardiovascular diseases such as atherosclerosis and cerebral aneurysms are caused by the degeneration of blood vessel wall, which is initiated by hemodynamic forces, particularly wall shear stresses. Therefore it is important to simulate the blood flow and the blood vessel wall as well as the interaction between them. In order to achieve a realistic in-vivo simulation, modeling of appropriate boundary conditions is a crucial issue. The aim of the present research is to develop a numerical simulation system, which considers the interaction between the blood flow and the blood vessel wall of the middle cerebral artery using finite element method, as well as the effect of the peripheral vessels network of the cerebral arteries. The peripheral vessels network was modeled using coupling multi-scale model of 1D and STI (Structure Impedance Model), and then applied as outflow boundary condition to the 3D simulation of patient specific model.
