Abstract
Thrombus often results in severe disease in heart or brain In order to develop effective prevention or treatment for thrombus, it is necessary to reproduce thrombus formation numerically and clarify the detailed mechanism of platelet activation. In this paper, therefore, numerical modeling for platelet activation process is proposed and the coupled analyses with advection-diffusion of ligands are demonstrated. The model is roughly divided into two parts, advection-diffusion of ligands in blood flow and platelet activation. The platelet activation process is simplified and consists of ligand-receptor bonding, increase of concentration of calcium ion in a platelet, secretion of ligands, GPIIb/IIIa activation, and chain-reactions of these processes. Numerical results show time course of advection-diffusion of ADP in blood flow, ADP-P2Y1 and ADP-P2Y12 bonding, successive secretion of dense granule from activated platelets, and the promotion of the activation of surrounded paltelets by secreted ligands.
