Abstract
Although traumatic brain injuries are caused by rotational impact, the effect of the rotational impact on cell damage is not entirely understood. In previous study, the reconstruction analysis of accident using the head finite element model shows the impact loaded by the rotational acceleration is easier to cause brain injury than by the linear acceleration. However, in vitro experiment taken in consideration of the rotational acceleration that generates biaxial strain with in test specimen is not conducted. This study designs and develops a device that exposes neurons cultured on the gelatinous specimen to biaxial strain generated by the rotational impact. The major components of the device are servo motor, encoder, controller, and dish with the gelatinous specimen. We validate whether the strain field of the gelatinous specimen mimics the deformation induced by head impact and evaluate the tolerance of cultured neuron for biaxial strain.
