Abstract
Cancer is one of the major diseases that cause death all over the world. One of the first steps of metastasis is lymphatic metastasis. Systemic drug administration, which is major chemotherapeutic approach is of minor benefit for the metastatic lymph nodes and causes strong side effects. In our laboratory, we have studied on a novel drug delivery system, combining nano/microbubbles with ultrasound (US), which shows considerable potential for the delivery of exogenous polymeric molecules into lymph node cells through the lymphatic sinus. In this study, we selected some fluorescent molecules with different molecular weight (MW) as exogenous molecules, and evaluated delivery efficiencies into tumor cells in the metastatic lymph node depending MW. We found that delivery efficacy into lymph node cells has difference between MW.
