Abstract
By investigating the interactions between luciferase and Si substrates using molecular dynamics (MD) simulation, we got the following results. Luciferase adsorbs directly on the hydrophobic Si substrate, and via water molecules on the hydrophilic one. Luciferase adsorbs more strongly on the hydrophobic Si substrate than on the hydrophilic one. Flexibility of luciferase is reduced when luciferase adsorbs on the Si substrate.
