Abstract
To erect the method that rates the dynamic deformability of erythrocytes, we propose a new dynamic model of an erythrocyte with formulation of the external force distorts erythrocytes as be proportional to the velocity of the moving plate of experiment system through viscosity coefficient. In this research, we entertain the possibility of our new dynamic model to discern clinical condition mice from normal. By experiments using the rheoscope method with parallel glass plate, we got time series of images, which comprehends deformation and travel distance of erythrocytes. To identify parameters in the model, we used the least square method and the optimization method based on deformation and travel distance of erythrocytes in the experimental data. We validate our method applying to normal mice erythrocytes and hardened by glutaraldehyde. Then we apply our method to clinical condition mice to recognize the dynamic deformability of erythrocytes in clinical condition.
