Abstract
Natural vibration analysis of cell adhesion molecules on membrane was performed by FEM in order to access the mechanism of cells sensing external vibration. According to past studies, it was revealed that cells change themselves to adapt to the environment under mechanical stimulus. We have also found crucial phenomenon that cells respond to vibration with proliferation in the experiments. Considering the result of the experiments, it should be understood that cells may have sensors for vibration and molecules for cell adhesion may be one of the sensors. However the mechanism how the molecules may sense vibration and translate the mechanical stimulus into chemical signals has not been understood. It has also been revealed that cells respond to the specific frequencies. Therefore we hypothesize that the sensors may resonate at the frequencies and translate vibration into signals. In order to access the hypothesis, we constructed a dynamical model of cell adhesion molecules and conducted natural vibration analysis in this study. As a result, it was suggested that the molecules for cell adhesion has natural frequencies from the order of MHz to THz. These results indicate the molecules may sense vibration and translate vibration into signals at this order of frequencies, in which the instrument for repair a broken bone works.
