Host: The Japan Society of Mechanical Engineers
Name : Dynamics and Design Conference 2018
Date : August 28, 2018 - August 31, 2018
The brain is exposed to light, magnetic field, chemical stimulation, and mechanical stimulation. These stimulations affect neurons constituting the brain. Neurons are known as their stretching axons and the information transmission in the brain is conducted by them. Action potentials generated by the information transmission are measured as brain waves and are used to study brain activity. They are classified according to their frequency range and the frequency range from 26 to 80 Hz is called the gamma wave region. The gamma wave are regarded as coordinating the activity between the nerves. Recently, it had been reported that the visual stimulation of light (60W, 40 Hz) excites the gamma wave region in the brain and that mechanical vibration promotes the proliferation and the differentiation of neural stem cells. We thought there are relationship between vibration in the gamma wave region and neurite outgrowth. Our goal is to verify the effect of mechanical vibration in the gamma wave region on neurite outgrowth. In this study, we used PC-12 which are also used to study signal transduction, differentiation, survival and proliferation mechanisms as they respond to many growth factors. We gave vertical sinusoidal to PC-12 and obtained that mechanical vibrations at 12.5 Hz (outside the gamma region) and 25 Hz (gamma region boundary) significantly enhanced neurite outgrowth compared to the non-vibration group but at 40, 50 Hz (gamma wave region), 100 Hz (outside the gamma wave region) significantly suppressed. We conclude that mechanical vibration in the gamma wave region may suppress neurite outgrowth.
