Host: The Japan Society of Mechanical Engineers
Name : Dynamics and Design Conference 2018
Date : August 28, 2018 - August 31, 2018
The effect of long term medium flow on bone cell proliferation was investigated experimentally. Mechanical stimulation is known to increase bone density and strength in our bodies due to the responses of cells inside bones. It is reported that cultured bone cell density is increased by mechanical vibration and its effect is dependent on the frequency. However, how cells respond to mechanical vibration is still unknown. A variety of chemical or physical phenomena should be induced by mechanical vibration. In order to understand the mechanism, we need to find out which of the phenomena largely affects cell proliferation. Previous experiment by our group has indicated that medium sloshing, one of the frequency dependent phenomena, affects bone cell proliferation. In this paper, in order to understand how the sloshing affects cell proliferation, we focused on one of the sloshing-induced phenomena, medium flow. Bone cells were cultured under medium flow which is generated by micro-pumps. Time over change of the cell density was measured and compared with that of controls and vibrations. The obtained result indicates that bone cell proliferation is increased by medium flow and its effect is about a half of that of mechanical vibration.
