Host: The Japan Society of Mechanical Engineers
Name : Dynamics and Design Conference 2019
Date : August 27, 2019 - August 30, 2019
The brain is exposed to light, magnetic field, chemical stimulation, and mechanical stimulation. These stimulations affect neurons constituting the brain. Neurons are known as their stretching axons and the information transmission in the brain is conducted by them. Action potentials generated by the information transmission are measured as brain waves and are used to study brain activity. They are classified according to their frequency range and the frequency range from 26 to 80 Hz is called the gamma wave region. The gamma wave region are regarded as coordinating the activity between the nerves. Recently, it had been reported that the visual stimulation of light (60W, 40 Hz) excites the gamma wave region in the brain and that mechanical vibration promotes the proliferation and the differentiation of neural stem cells. We thought there are relationship between mechanical vibration and neurite outgrowth. Our goal is to verify the effect of mechanical vibration on neurite outgrowth. In this study, we used PC-12 which are also used to study signal transduction, differentiation, survival and proliferation mechanisms as they respond to many growth factors. We gave vertical sinusoidal considering medium sloshing to PC-12 and obtained that mechanical vibrations at 25 Hz (gamma wave region boundary) and 40, 50 Hz (gamma wave region) significantly suppressed neurite outgrowth compared to the non-vibration group. Compared with the previous report, it was concluded that shear stress resulting from sloshing promotes neurites and mechanical vibration may suppress neurite outgrowth.
