Abstract
In this paper, we propose a fracture model of islets in a shear flow to evaluate the mechanical damage of islets. The fracture model was developed using the relationship between surface area increase and strain energy induced into the islet through the fracture. The islet diameter reduction during the purification process was predicted using the fracture model and numerical calculation using computational fluid dynamics. Comparing experimental and numerical results in terms of the islet size reduction, it is confirmed that the fluid dynamical stress during the islet purification damages islets.
