Abstract
Cell electroporation using focused electric field by a micro-orifice in a thin insulating plate has potential to directly deliver the foreign molecules into a nucleus.This paper gives an insight into the mechanism of the direct delivery of the molecules by numerically analyzing the membrane potential of a nucleus and a cell trapped on the micro-orifice.The results show that the focused field enhances the buildup of the nucleus membrane voltage and may contribute to improve the molecular permeability of the nucleus membrane.
