Host: The Japan Society of Mechanical Engineers
Name : [in Japanese]
Date : March 06, 2021
The purpose of this study was to evaluate the effect of the elastic modulus gradient on the osteoclastic dissolution behavior of the polymer-blend substrate systems. Here, polycaprolactone (PCL) and polylactic acid (PLA) were used to prepare the polymer-blend substrate systems. As the reference materials, neat PCL and PLA substrates were also prepared. The osteoclasts were differentiated from the hematopoietic stem cells. The osteoclastic substrate dissolution behavior was evaluated using a FT-IR. As a result, the activation of the osteoclasts was evident on the neat PLA substrate rather than on the neat PCL substrate, owing to their elastic modulus. In addition, it was confirmed that osteoclasts were more activated on the PLA side, which has the higher elastic modulus, than on the PCL side. It was also confirmed that the difference in the activation degree of osteoclasts decreased with increasing culture period. Therefore, it can be considered that the elastic modulus gradient function of the prepared polymer-blend substrates would be successfully achieved, resulting in the regulation of the osteoclastic activity.
