In nuclear power plant, the phenomenon of liquid film breakdown in corrugated-plate separator is common and affects its separation efficiency. The flow behavior of liquid film that fell down along the vertical plate and was driven by airflow was so complicated in the separator that the full attention was paid in this paper. The dynamics and the breakdown of liquid film were determined by such factors as gas velocity, thickness and falling velocity of liquid film and the property of fluids. Based on the conservation of energy, the criterion for predicting liquid film separation was established. Comparisons of the experimental data and the results of the theoretical model showed that the prediction of breakdown of liquid film at the corner was accurate.