Abstract
We have been developing two types of next-generation, a pulsatile totally implantable artificial heart and a nonpulsatile centrifugal blood pump (CP). The pulsatile device is an electrohydraulic artificial heart with right and left di aphragm type artificial ventricles activated alternately by an intracorporeal regenerative pump as an actuator. The nonpulsatile device is a no-seal and no-shaft CP featuring self-irrigation of an impeller. The feasibility of the pumps was assessed. The results indicated that these pumps fulfilled basic requirements for a long-term device although est ablishment of adequate control is necessary to overcome changes of hemodynamics in a living body. Pathophysiology of recipients of such devices were analyzed and new technologies to carry out research and development of the arti ficial hearts were efficiently applied.
