Abstract
Von Willebrand Factor(VWF) plays an important role in regulation of hemostasis and thrombosis formation under high shear rate. We obtained the force curve for the interaction between VWF and GPIbot by atomic force microscope. Some of the force curves showed the multiple peaks, indicating the unfolding of A2 domain of the VWF. The unfolding of VWF may cause the conformational change of VWF.
