S022032 Indentation Analysis of Tamoxifen-Resistant MCF-7 cells by Using Atomic Force Microscope

Abstract

In this paper, we measure the elastic modulus of cell surface by indentation test with an atomic force microscope for each of tamoxifen sensitive and resistant breast cancer cell lines. From the comparison of measurements based on statistical test, we demonstrate that tamoxifen resistant cells might be 28% "softer" than sensitive cells, which evokes the necessity of biomechanistic point of view in cancer research.