J026021 Development of Microcapsules including gas bubbles for regenerative medicine by shockwaves.

Abstract

This paper describes development of regenerative medical system using microcapsules including gas by shock waves. The newly proposed system has two features. One is culture mode by pressure wave , the other is rupture mode by interactions between shock waves and bubbles in microcapsules. Especially, the disintegration mechanism of polymer capsules including gas bubbles by shock wave was investigated in this paper. Deformation process of a capsule and a bubble were observed by microscopy. It was found that there are three modes such as no oscillation, oscillation, disintegration (damage) after working pressure wave (414kHz frequency) on the microcapsules. These modes show the threshold which shows the boundary of damage of a capsule, and no damage. These results serve useful data for developing of microcapsule to cultivate cells.