To provide basic data for assistance of the development of the medical guide-wire, we examined the mechanical properties of the guide-wire in blood vessel model. As the first step of this study, we noticed the rotation of the guide-wire, and measured torque transmission and rotational response of the guide-wire in the blood vessel model. Material of the blood vessel models are PVA-H (polyvinyl alcohol hydrogel ) and PVA-H(D) which mixed DMSO to PVA-H. Shape of the blood vessels model is square pillar, and the guide-wire was inserted in the central hole. During the experiment of torque transmission measurement, the torque meter was attached to both ends of the guide-wire. Rotational torque was generated by stepping motor of the proximal end side. During the experiment of the rotation response measurement, two arms were attached to both ends of the guide-wire, and their rotational angle were taken by video camera. As the result, we found that the greater stiffness of blood vessel model and proximal rotational speed affect the torque and rotational losses of guide-wire.