In recent years, there has been increased the osteoporosis patient, and it has become important to elucidate how the bone loss of lumber vertebra has an influence on the compression fracture. This study investigated the stress and deformation of the osteoporotic lumber vertebra injected by bone cement during prolonged uniform load using the growth-strain method. First, 3D FEM models on the lumber vertebras and lumber vertebras injected by bone cement with bone loss 30, 50% were determined by changing the Young's modulus. Then, growth criterion parameters of the strain energy density on various parts of the lumber vertebra were determined by analyzing these FEM models. Finally, the strain energy density of osteoporotic cervical spine models injected by bone cement receiving the uniform load were analyzed using the growth-strain method, and the bone growth behavior was compared. As a result, it was clarified that the 4th lumber vertebra had highest risk of the compression fracture.