In this paper, a number of artificial earthquake ground motions compatible with non-stationary time-frequency characteristics as well as the given target response spectrum are generated using wavelet transform. The maximum displacement, velocity and acceleration responses of elasto-plastic structures by excited these artificial earthquake ground motions are calculated numerically. Displacement response, velocity response and cumulative input energy are shown in the case of the ground motion which cause larger displacement response. Under the given design response spectrum, a selection manner of generated artificial earthquake ground motion which causes larger maximum displacement response of elasto-plastic structure are suggested.