F021003 Dynamic Behavior of Nerve Cells and Blood Brain Barrier under Impulsive Load

Abstract

The presentation is aimed for the prospective contribution of biological experiment to TBI research. The axonal injury of nerve cells and collapse of blood brain barrier system are spotlighted. With a background of rapid development of computational mechanics, injury threshold for impulsive load and morphological change after injury of cells and blood vessels are becoming more important. The injury threshold of nerve cells with direction controlled axon which was stretched uniaxially was evaluated. And BBB model exposed to impulsive pressure fluctuation was evaluated by measuring the TEER.