Elucidation of underwater locomotion of neutrophil by concentration gradient of cytokine

Abstract

Neutrophil is known as one of the immunological system, and it has chemotaxis by concentration gradient of cytokine. In general, the neutrophil is moved to high concentration of cytokine in the blood vessel, and derived to the inflammation areas. However, the mechanism of propulsion has not been elucidated yet. By understanding this mechanism, it can be applied to medical technologies such as drug delivery systems and micro machines. Therefore, it is necessary to elucidate the principle of neutrophil's propulsion. In our previous investigation, it was found that concentration gradient on the surface of neutrophil is reverse toward surrounding fluid. In this paper, detailed concentration distribution and concentration gradient on the neutrophil's membrane are examined by experimental. From the result, It was found that concentration gradient occurred by the decreasing of concentration at the neutrophil's membrane of cytokine insert side.