Host: The Japan Society of Mechanical Engineers
Name : [in Japanese]
Date : September 03, 2017 - September 06, 2017
In this study, we investigated the resorption behavior for the substrates due to the osteoclasts cultured on the substrates with different elastic moduli in order to investigate the interaction between the metabolic behavior of osteoclasts and the mechanical properties of the substrates. Here, PCL substrates with different elastic moduli were prepared by changing the cooling rate. After osteoclasts were cultured on the prepared substrates, the elastic modulus and yield strength were evaluated by tensile tests. As a result, in the rapidly cooled PCL, the elastic modulus and the yield strength of the substrate decreased due to the resorption behavior by osteoclasts and hydrolysis. On the other hand, the elastic modulus and yield strength of the slowly cooled PCL decreased by hydrolysis, whereas it did not decrease due to resorption behavior of osteoclasts. Based on these results, the mechanism of the interaction between the metabolic behavior of osteoclasts and the dissolution behavior of the substrates was discussed.
